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Figure 4 | BMC Physiology

Figure 4

From: Forced expression of the cell cycle inhibitor p57Kip2 in cardiomyocytes attenuates ischemia-reperfusion injury in the mouse heart

Figure 4

p57Kip2 protects hearts from ischemia/reperfusion (I/R) injury in the Langendorff isolated perfused heart model. Upper Panel: Representative hemodynamic tracings from Langendorff isolated perfused heart from a control and a R26loxpTA-p57k/+;Mlc2v-Crek/+animal. Real-time condensed recordings of hemodynamic parameters (LVP=left ventricular pressure, LVSP=left ventricular systolic pressure, LVEDP=left ventricular end diastolic pressure, dp/dt(max/min) and HR) are shown. Lower Panel: Representative sections of a control (left) and a R26loxpTA-p57k/+;Mlc-2v+/- (right) heart. The hearts were sliced into sections and stained with 2,3,5-TTC followed by formalin fixation. Viable tissue is stained brick red, while infarcted areas are white. Note the more significant necrotic area (black arrow) in the injured, control heart.

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