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Table 3 Phenotypes in the Irwin observational panel

From: An extensive phenotypic characterization of the hTNFα transgenic mice

Observation Genotype Males Females
Body weight (g) WT 31.5 ± 18.8 20.3 ± 0.9
  TG 25.5 ± 1.7* 22.2 ± 0.9
Body length (mm) WT 92.8 ± 0.9 86.6 ± 0.5
  TG 89.4 ± 1.0* 87.8 ± 1.1
Grip strength (score 0–4) WT 2.4 ± 0.2 1.0 ± 0
  TG 0.8 ± 0.2** 1.6 ± 0.2
Wire maneuver (score 0–4) WT 1.4 ± 0.2 2.8 ± 0.5
  TG 4.0 ± 0*** 2.0 ± 0.6
Tail elevation (score 0–2) WT 2.0 ± 0 1.4 ± 0.2
  TG 1.2 ± 0.2* 1.2 ± 0.2
  1. Values represent the mean ± SEM n = 5 mice for each sex/genotype combination. The level of significance is shown by asterisks: * P < 0.05, ** 0.001 <P < 0.01, *** P < 0.001. For scoring description see Methods section for Irwin observational panel.