From: An extensive phenotypic characterization of the hTNFα transgenic mice
Therapeutic Field | Bioassays | Phenotype |
---|---|---|
Cardiovascular, renal and bladder function | Bladder function (F) | NS |
Blood pressure/heart rate (M) | ↑(BP)* | |
Urine chemistry panel (F) | NS | |
CNS and Behavior | Irwin test (M,F) | ↓*** |
Cross-therapeutic assays | Automated blood chemistry panel (M) | NS |
Body weight measurements (M,F) | NS | |
Corticosterone (M) | ↑* | |
Immunology and Inflammation | DTH (M) | NS |
FACS analysis (M) | ↓* | |
LPS challenge (M) | NS | |
Monocyte infiltration (F) | ↑* | |
Pulmonary inflammation (F) | NS | |
Wound healing (F) | NS | |
Metabolism and Body Composition | DEXA (F) | ↓* |
Excised bone DEXA (F) | ↓** | |
Food intake (M,F) | NS | |
Food intake on HFD (M) | ↑*** | |
Leptin (M,F) | ↓** | |
Metabolic response to HFD (M) | ↑** | |
Physical response to HFD (M) | ↓*** | |
Selected muscle weight (F) | ↓** | |
Pain | Formalin pain assay (M) | NS |
Hot-plate assay (F) | NS | |
Sexual health | Histopathology of reproductive system (M) | NS |
Induced erection test (M) | ↓* | |
Male contact sexual behavior (M) | ↓*** | |
Male fertility (M) | ↓*** | |
Testosterone (M) | NS |