Body Weights. TG males were significantly lighter than WT males and the weight of TG females did not increase over time like WT females (A) Weights of male WT (open squares n = 4) and TG (black triangles n = 4) mice between 15 and 26 weeks of age. (B) Weights of female WT (open squares n = 6) and TG (black triangles n = 6) mice between 15 and 28 weeks of age. Results represent the mean ± SEM. The level of significance is shown by asterisks: * P < 0.05, ** 0.001 <P < 0.01, *** P < 0.001 in the post-hoc analysis.