Figure 1From: PI3K and PKC contribute to membrane depolarization mediated by α2-adrenoceptors in the canine isolated mesenteric veinThe α 2 -adrenoceptor blocker yohimbine reduces the contractile responses of canine isolated mesenteric vein to norepinephrine (NE) and clonidine. Contractile responses of control and yohimbine-incubated tissues (0.1 μM, 30 min) to exogenous NE (A) and clonidine (0.05–10 μM each). Contractile responses were expressed as percentage of the contractile response to 70 mM KCl. Data are presented as mean ± SEM, n = 4–8. *, P < 0.05. Representative traces of intracellular recordings of membrane potential changes elicited by NE (0.1 μM, 30 s, panel C) or clonidine (1 μM, 30 s, panel D). Scale bars apply to traces C and D.Back to article page