Skip to main content

Table 6 T3 and GH have overlapping effects on gene expression in liver.

From: Exploring hepatic hormone actions using a compilation of gene expression profiles

Accession

Name

T3/untreated

young_GH

old_GH

  

AW140999

cytochrome P450 4A3

9.77

0.88

0.53

  

AA956687

malic enzyme 1

7.86

2.21

2.64

*

#

BC029693

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1

6.82

1.42

1.79

  

NM_145878

fatty acid binding protein 5, epidermal

6.59

2.02

1.46

*

#

K01934

thyroid hormone responsive protein

5.69

1.50

1.31

  

AW142176

similar to Igh-6 protein

5.20

NA

1.70

  

AW140621

similar to coenzyme A diphosphatase

4.94

0.90

1.37

 

#

AA925003

cytosolic acyl-CoA thioesterase 1

4.64

1.12

1.63

*

 

AW916988

sterol-C5-desaturase (fungal ERG3, delta-5-desaturase)-like

4.51

1.43

1.50

 

#

AW142891

EST

4.41

1.10

1.18

  

AA924590

FXYD domain-containing ion transport regulator 2

4.36

1.02

0.69

  

BF281499

signal transducer and activator of transcription 5B

4.29

NA

1.07

  

AA819712

EST

4.22

NA

1.13

  

X16417

hemoglobin beta chain complex

4.13

0.91

1.25

  

M34477

farensyl diphosphate synthase

3.96

2.01

1.50

 

#

NM_013096

hemoglobin, alpha 1

3.79

0.92

1.39

*

 

AW916676

EST

3.79

0.91

1.53

  

AW140468

hypothetical protein LK44

3.70

1.37

1.01

*

 

AA923919

cathepsin E

3.63

NA

NA

  

AW916686

similar to HT021

3.63

0.89

1.68

*

 

AW142204

peptidyl arginine deiminase, type 4

3.59

0.92

1.44

*

 

AA860063

similar to Glutathione S-transferase, theta 3

3.56

1.14

0.75

  

X62888

fatty acid synthase

3.55

2.18

1.74

*

#

AW142682

podocalyxin-like

3.52

NA

NA

  

AA957248

fatty acid elongase 1

3.50

1.08

1.20

*

 

AA818305

similar to putative NAD(P)H steroid dehydrogenase

3.44

1.26

1.45

 

#

AA956747

fatty acid desaturase 2

3.33

1.11

1.51

*

 

AW918434

hypothetical protein RMT-7

3.31

0.90

0.39

*

 

AA997956

2,3-oxidosqualene: lanosterol cyclase

3.29

1.63

1.43

*

 

CB736793

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 5

3.24

1.59

1.23

 

#

AW141045

multiple inositol polyphosphate histidine phosphatase 1

3.21

0.92

1.38

*

 

AW142257

similar to hemoglobin alpha chain

3.19

0.93

1.45

*

 

AW142786

Na+ dependent glucose transporter 1

3.17

0.98

1.22

  

AA858817

EST

3.05

NA

0.94

  

M31672

insulin-like growth factor binding protein 2

2.95

NA

1.08

*

 

AA998020

protein O-mannosyltransferase 1

2.95

NA

NA

  

AW913874

adipose differentiation-related protein

2.93

1.61

0.95

*

 

AA924800

3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1

2.88

NA

NA

  

AA819200

similar to Alcohol sulfotransferase (Hydroxysteroid sulfotransferase) (ST) (ST-60)

2.86

3.01

2.44

 

#

AI045953

cysteine-sulfinate decarboxylase

2.83

0.54

0.61

  

NM_012598

lipoprotein lipase

2.78

NA

NA

*

 

AI029316

folylpolyglutamyl synthetase

2.72

1.31

1.07

*

 

AA817840

opioid receptor, sigma 1

2.68

1.19

1.89

*

#

BF282623

EST

2.63

1.01

1.06

  

AI137633

Nrp: neuropilin

2.59

NA

1.16

  

AW914056

growth response protein (CL-6)

2.58

2.30

1.48

 

#

AI059131

2-4-dienoyl-Coenzyme A reductase 2, peroxisomal

2.56

NA

NA

  

M73714

aldehyde dehydrogenase family 3, subfamily A2

2.55

0.96

1.20

*

 

J02585

stearoyl-Coenzyme A desaturase 1

2.53

1.35

1.14

  

NM_007760

carnitine acetyltransferase

2.51

NA

1.19

*

 

AA819496

hypoxia induced gene 1

2.49

NA

0.79

  

AW916795

occludin

2.49

0.94

1.01

  

BF281801

kinesin family member 1B

2.44

0.68

1.28

*

 

AF007775

aquaporin 8

2.42

1.21

1.86

*

#

AW916443

EST

2.32

0.95

0.92

  

AW915619

inositol 1,4,5-triphosphate receptor 1

2.32

0.90

1.32

*

 

AB012933

fatty acid Coenzyme A ligase, long chain 5

2.30

2.55

1.79

 

#

AA964037

phospholipase A2, group VI

2.26

NA

NA

  

AI044427

similar to myotonic dystrophy protein kinase

2.17

NA

1.20

*

 

AW913988

GTP cyclohydrolase 1

2.17

0.83

1.29

*

 

M95591

farnesyl diphosphate farnesyl transferase 1

2.16

1.02

1.15

*

 

AA998726

nasal embryonic LHRH factor

2.12

NA

0.92

*

 

AW916626

EST

2.09

1.07

0.90

  

AW140633

hemoglobin Y, beta-like embryonic chain

2.08

0.97

1.37

  

AA926032

enoyl coenzyme A hydratase 1

2.05

0.91

1.19

*

 

AA925091

fatty acid binding protein 4

2.01

NA

NA

  

AA925731

isocitrate dehydrogenase 1

2.00

NA

NA

*

 
  1. All of the genes in this list were up-regulated by T3 in hypothyroid mice (ratio repeatedly larger than 2). Clones that did not map to any Unigene cluster were removed. The genes that were included in the promoter analysis, where mouse and human orthologs could be found, are indicated with a *. The genes that were up-regulated by continuous infusion of GH in at least one of the in vivo models in a statistically significant manner are indicated with a #. The table shows Unigene ID, GenBank accession number, gene name, and the median ratio (treated/untreated). "NA" means that the gene was flagged away in the analysis due to low expression in two or more hybridizations. The shown experiments are: T3: thyroid hormone treatment of hypothyroid mice for 2 hours; Young GH: infusion of bovine growth hormone (bGH) in young (3 months) male rats for 7 days; Old GH: infusion of human growth hormone (hGH) in old (2 years) male rats for 3 weeks.
Back to article page

BMC Physiology

ISSN: 1472-6793

Contact us