Figure 2From: Endothelial [Ca2+]i is an integrating signal for the vascular tone in rat aortaeAgonist-induced EC [Ca2+]i elevation and vasorelaxation. A typical example of endothelial [Ca2+]i and corresponding vascular response to cumulative concentrations of ACh (a) or ionomycin (b) in a PE pre-contracted aortic en face preparation. The dash and solid arrows indicate the time of application of PE and agonists, respectively. Both agonist-induced EC [Ca2+]i elevation (●) and corresponding vasorelaxation (○) increase in a dose-dependent manner.Back to article page